PROGRAM PROJECT GRANTSINNATE IMMUNITY: ELUCIDATION/ MODULATION CANCER THERAPY Michael Caligiuri, MD, lead investigator – Department of Internal Medicine, Division of Hematology and Oncology. This PPG stresses innovative clinical cancer immunotherapy trials based on current understanding of innate immunology, as well as basic investigation into innate immune effector cell function in preparation for subsequent, more refined clinical cancer immunotherapy trials. Project 1: Innate immunity: elucidation/modulation - cancer therapy – John Byrd, MD, and Pierluigi Porcu, MD Project 2: Homeostatic control of FcyR-triggered macrophage function – Susheela Tridandapani, PhD Project 3: Immune regulation of natural killer (NK) cell subsets – Michael Caligiuri, MD, Sherif Farag, MD, PhD, and Ramana Davuluri, PhD Project 4: Two signal requirements for NK immunity – William Carson III, MD GENETIC AND CLINICAL RISK FOR HUMAN SLE NEPHRITIS Project 1: Genetic variants of CR1 and FcR in human SLE nephritis – Daniel Birmingham, PhD Project 2: Complement C4 and HLA class III genes in human genes in human SLE – Chack-Yung Yu, PhD Project 3: Chemokine regulation in human SLE nephritis – Brad Rovin, MD Project 4: Pathogenesis of SLE relapse in humans – Lee Hebert, MD DNA METHYLATION AND CHROMATIN MODIFICATIONS: MECHANISMS AND APPLICATIONS IN CANCER Project 1: Clinical investigation of epigenetic therapy – John Byrd, MD Project 2: Identification of methylated genes in chronic lymphocytic leukemia – Christoph Plass, PhD Project 3: Altered expression of protein tyrosine phosphatase by methylation: potential role in tumor suppression – Samson Jacob, PhD Project 4: Histone modification and changes in chromatin: silencing of tumor-suppressor genes – Mark Parthun, PhD Project 5: Brg1 and hBrm-associated histone methyltransferase: target genes in cancer therapy – Saïd Sif, PhD GENETIC ANALYSIS OF THE BREAST TUMOR MICROENVIRONMENT Project 1: Genetic alterations in the epithelial and stromal compartments of breast adenocarcinomas – sub-grant with Cleveland Clinic Foundation – Charis Eng, MD, PhD Project 2: Role of Rb and E2Fs in regulating stromal/ epithelial interactions during mammary carcinogenesis – Gustavo Leone, PhD Project 3: Role of the Ras/ets-2 pathway in breast tumor progression – Michael Ostrowski, PhD MECHANISMS OF CHRONIC PATHOBIOLOGY IN ALLOGRAFTS Project 1: Role of alloantibodies in allograft pathobiology – Ronald Pelletier, MD Project 2: Role of macrophages in remodeling and rejection of solid organ transplants – Clay Marsh, MD Project 3: Myofibroblasts and fibrositis after cardiac transplant – Arthur Strauch, PhD INTEGRATED CANCER BIOLOGY PROGRAM (ICBP) COLLABORATIVE AGREEMENTINTERROGATING EPIGENETIC CHANGES IN CANCER GENOMES Project 1: Dissecting hierarchies of epigenetic control in gene silencing – Tim Hui-Ming Huang, PhD Project 2: Integrating genomic and epigenomic alterations in cancer and its microenvironment – Shili Lin, PhD Project 3: Chromatin landscaping of TGF-P/SMAD signaling targets – Ramana Davuluri, PhD Project 4: Predicting drug resistance in cancer genomes by DNA methylation profiling – Tim Hui- Ming Huang, PhD SPECIALIZED CENTER GRANTSSPECIALIZED CENTER OF RESEARCH: EXPERIMENTAL THERAPEUTICS IN CLL Project 1: Pre-clinical and clinical development of flavopiridol in CLL – Michael Grever, MD Project 2: Chromatin remodeling as a therapeutic target to enhance biolic therapies in CLL – Michael Freitas, PhD Project 3: Therapeutic targeting of novel kinases in CLL – John Byrd, MD Project 4: Molecular target-based therapeutics for CLL – Ching-Shih Chen, PhD REDUCING CERVICAL CANCER IN APPALACHIA Project 1: Cervical cancer screening among Appalachian populations – Electra Paskett, PhD Project 2: Tobacco use and cessation among Appalachian women – Mary Ellen Wewers, PhD Project 3: Correlates of abnormal pap smears in Appalachia – Electra Paskett, PhD Project 4: Appalachia, diversity training supplement– Kimberly Kelly, PhD CORE GRANTSOSU COMPREHENSIVE CANCER CENTER SUPPORT GRANT (OSUCCC) OSU NEUROSCIENCE CORE Core A: Administration – PI, John Oberdick, PhD Core B: Genetics (transgenic mouse & zebra fish) – PI, Anthony Young, PhD Core D: Electrophysiology – PI, Mike Xi Zhu, PhD Core E: Confocal microscopy – PI, Anthony Brown, PhD |
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