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Methotrexate

Methotrexate lowers your immune system and has a potential benefit in treating Multiple Sclerosis (MS). Weekly doses of Methotrexate may delay progression of MS. Methotrexate may be taken with other disease modifying drugs or as a single therapy.

  • Each Methotrexate tablet is 2.5 mg. Take prescribed number of tablets on the same day, ONCE A WEEK.
  • Keep Methotrexate away from excessive heat, light and moisture.  Keep out of reach of children.
  • You must have bloodwork drawn to monitor for side effects. Bloodwork includes a CBC, ALT, AST and Creat. Your doctor will tell you how often this must be completed.
  • Folic Acid 1 mg daily will be prescribed while taking Methotrexate to prevent any red blood cell abnormalities (anemia). This is a prescription strength supplement. Over the counter preparations are not adequate.
  • Your physician may order a Chest X-ray before you start treatment and then yearly.
  • Alcohol can increase the risk of liver problems while taking Methotrexate.
  • Check with your doctor before taking any of the following over the counter medications.  These medications may increase the effects of Methotrexate.
    • Aspirin
    • Ibuprofen (Advil, Motrin, Nuprin)
    • Naproxen (Naprosyn, Aleve, Naprelan)
  • Notify all your doctors and your pharmacist that you are taking Methotrexate. Prescription drugs may also increase the effects of Methotrexate.
    • Antibiotics (Sulfa, Bactrim,Septra)
    • Phenytoin (Dilantin)
    • Anticoagulants (coumadin)
  • You may take Tylenol as needed.
  • If you are a woman, you should not get pregnant. Methotrexate may harm your unborn baby. Please discuss with your doctor.
  • You may be more sensitive to sunlight, so avoid excessive sun exposure, tanning booths or sunlamps.
  • Methotrexate may cause temporary thinning of hair

Side Effects Needing Immedtiate Attention

  • Black, tarry stools
  • Vomiting blood
  • Fever over 101  degrees Fahrenheit  
  • Convulsions (seizures)

Side Effects Needing Attention as Soon as Possible

  • Dark or bloody urine
  • Blurred vision
  • Sores in the mouth or on the lips
  • Chronic cough not related to an infection or allergy
  • Stomach pain
  • Unusual bleeding
  • Confusion
  • Diarrhea
  • Unusual bleeding or pinpoint red spots on skin
  • Shortness of breath
  • Dizziness
  • Headache
  • Pain in the joints
  • Unusual swelling of feet or lower legs
  • Unusual tiredness or weakness
  • Yellow eyes or skin